Publications

Selected Publications by CLUE Investigators

Late-Onset Unexplained Epilepsy

  • Johnson EL, Krauss GK, Lee AK, Schneider ALC, Dearborn JL, Kucharska-Newton AM, Huang J, Alonso A, and Gottesman RF. Association between midlife risk factors and late-onset epilepsy: Results from the Atherosclerosis Risk in Communities Study. JAMA Neurology. 2018;75(11):1375-1382.  PDF
  • Sarkis RA, Willment KC, Pennell PB, Marshall G.  Late-onset unexplained epilepsy:  What are we missing?  Epilepsy Behav. 2019 Oct:99:106478.  PDF
  • Sarkis RA, Beers L, Farah E, Al-Akaidi M, Zhang Y, Locascio JJ, Properzi MJ, Schultz AP, Chhatwal JP, Johnson KA, Sperling RA, Pennell PB, Marshall GA. The neurophysiology and seizure outcomes of late onset unexplained epilepsy. Clin Neurophysiol. 2020; 11: 2667-2672.  PDF
  • Johnson EL, Krauss GL, Walker KA, Brandt J, Kucharska-Newton A, Mosley TH, Yasar S, and Gottesman RF. Late-onset Epilepsy and 25-year Cognitive Change: The Atherosclerosis Risk in Communities Study. Epilepsia. 2020:61(8):1764-1773.  PDF
  • Johnson EL, Krauss GL, Kucharska-Newton A, Albert Marilyn S, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel K, and Gottesman RF. Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities Study. Neurology. 2020:95(24):e3248-e3256.  PDF
  • Johnson EL, Krauss GL, Kucharska-Newton, Lam AD, Sarkis R, Gottesman RF. Mortality in Patients with Late-Onset Epilepsy: Results from the Atherosclerosis Risk in Communities Study.  Neurology. 2021 Sep 14;97(11):e1132-e1140.  PDF
  • Blank LJ, Acton EK, Willis AW.  Predictors of Mortality in Older Adults with Epilepsy:  Implications for Learning Health Systems.  Neurology. 2021 Jan 5;96(1):e93-e101. PDF
  • Blank LJ, Agarwal P, Kwon C-S, Jette N. Association of first anti-seizure medication choice with injuries in older adults with newly diagnosed epilepsy.  Seizure 2023 Jul:109:20-25.  PDF
  • Johnson EL, Sullivan KJ, Schneider ALC, Simino J, Mosley TH, Kucharska-Newton, Knopman DS, and Gottesman RF.  Association of Plasma AB42/AB40 Ratio and Late-Onset Epilepsy: Results from the Atherosclerosis Risk in Communities Study.  Neurology. 2023 Sep 26;101(13):e1319-e1327.  PDF
  • Gugger JJ, Walter AE, Diaz-Arrastia R, Huang J, Jack CR, Reid R, Kucharska-Newton AM, Gottesman RF, Schneider ALC, and Johnson EL.  Association between structural brain MRI abnormalities and epilepsy in older adults.  Ann Clin Transl Neurol.  2024 Feb;11(2):342-354.  PDF
  • Carosella CM, Gottesman RF, Kucharska-Newton A, Lutsey PL, Spira AP, Punjabi NM, Schneider ALC, Full KM, and Johnson EL.  Sleep apnea, hypoxia, and late-onset epilepsy:  the Atherosclerosis Risk in Communities study.  Sleep. 2024 Jun 13;47(6):zsad233.  PDF

Epilepsy in Dementia / Alzheimer's Disease

  • Sarkis RA, Dickerson BC, Cole AJ, El-Chemali. Clinical and Neurophysiologic Characteristics of Unprovoked Seizures in Patients Diagnosed with Dementia. J Neuropsychiatry Clin Neurosci. 2016; 28:56-61. PDF
  • Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ.  Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease.  Nat Med. 2017 Jun; 23(6): 678-680.  PDF
  • Lam AD, Cole AJ, Cash SS.  New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer’s Disease.  Front Neurol. 2019 Sep 4; 10:959.  PDF
  • Lam AD, Sarkis RA, Pellerin KR, Dworetzky BA, Hoch DB, Jacobs CS, Lee JW, Weisholtz DS, Zepeda R, Westover MB, Cole AJ, Cash SS.  Association of epileptiform abnormalities and seizures in Alzheimer disease.  Neurology. 2020 Oct 20; 95(16): e2259-e2270.  PDF
  • Lam AD, Noebels J.  Night Watch on the Titanic:  Detecting Early Signs of Epileptogenesis in Alzheimer’s Disease.  Epilepsy Curr. 2020 Nov-Dec; 20(6): 369-374.  PDF
  • Blank LJ, Acton EK, Thibault D, Willis AW.  Neurodegenerative disease is associated with increased incidence of epilepsy:  a population based study of older adults.  Age Ageing. 2021 Jan 8;50(1):205-212.  PDF
  • Lam AD and Shafi MM.  Towards a coherent view of network hyperexcitability in Alzheimer’s disease.  Brain. 2022. Apr 18;145(2):423-425. PDF
  • Sarkis RA, Gale SA, Yang HS, Lam AD, Singhal T, Cicero S, Willment K, McGinnis SM.  Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline.  Am J Alzheimers Dis Other Demen.  2023 Jan-Dec:38:15333175231160005. PDF